CILIARY TIP ACTIN DYNAMICS REGULATE PHOTORECEPTOR OUTER SEGMENT INTEGRITY

Abstract As signalling organelles, cilia regulate their G protein-coupled receptor content by ectocytosis, a process requiring localised Dugouts actin dynamics to alter membrane shape.Photoreceptor outer segments comprise an expanse of folded membranes (discs) at the tip of highly-specialised connecting cilia, into which photosensitive GPCRs are co

Th17 cells and Foxp3+ regulatory T cells (Tregs) are thought to promote and suppress inflammatory responses, respectively.However, whether they counteract each other or synergize in regulating immune reactions remains controversial.To determine their interactions, we describe the results of experiments employing mouse models of intestinal inflammat